diff --git a/CMakeLists.txt b/CMakeLists.txt
index eda4f18..e0c286d 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -15,6 +15,7 @@ target_include_directories(uart_bridge PUBLIC
 	pico-sdk/lib/tinyusb/src)
 
 target_link_libraries(uart_bridge
+	hardware_flash
 	pico_multicore
 	pico_stdlib
 	tinyusb_device)
diff --git a/tusb_config.h b/tusb_config.h
index 7e0ec54..6fcb7b9 100644
--- a/tusb_config.h
+++ b/tusb_config.h
@@ -16,4 +16,6 @@
 #define CFG_TUD_CDC_RX_BUFSIZE 256
 #define CFG_TUD_CDC_TX_BUFSIZE 256
 
+void usbd_serial_init(void);
+
 #endif /* _TUSB_CONFIG_H_ */
diff --git a/uart-bridge.c b/uart-bridge.c
index aebbdf6..7ee6a9c 100644
--- a/uart-bridge.c
+++ b/uart-bridge.c
@@ -269,6 +269,8 @@ int main(void)
 
 	set_sys_clock_khz(250000, false);
 
+	usbd_serial_init();
+
 	for (itf = 0; itf < CFG_TUD_CDC; itf++)
 		init_uart_data(itf);
 
diff --git a/usb-descriptors.c b/usb-descriptors.c
index 5c10798..1ccd5de 100644
--- a/usb-descriptors.c
+++ b/usb-descriptors.c
@@ -9,6 +9,7 @@
  * Copyright (c) 2019 Damien P. George
  */
 
+#include <hardware/flash.h>
 #include <tusb.h>
 
 #define DESC_STR_MAX 20
@@ -36,6 +37,7 @@
 #define USBD_STR_MANUF 0x01
 #define USBD_STR_PRODUCT 0x02
 #define USBD_STR_SERIAL 0x03
+#define USBD_STR_SERIAL_LEN 17
 #define USBD_STR_CDC 0x04
 
 static const tusb_desc_device_t usbd_desc_device = {
@@ -68,10 +70,12 @@ static const uint8_t usbd_desc_cfg[USBD_DESC_LEN] = {
 		USBD_CDC_IN_OUT_MAX_SIZE),
 };
 
+static char usbd_serial[USBD_STR_SERIAL_LEN] = "000000000000";
+
 static const char *const usbd_desc_str[] = {
 	[USBD_STR_MANUF] = "Raspberry Pi",
 	[USBD_STR_PRODUCT] = "Pico",
-	[USBD_STR_SERIAL] = "000000000000",
+	[USBD_STR_SERIAL] = usbd_serial,
 	[USBD_STR_CDC] = "Board CDC",
 };
 
@@ -95,6 +99,7 @@ const uint16_t *tud_descriptor_string_cb(uint8_t index, uint16_t langid)
 		len = 1;
 	} else {
 		const char *str;
+		char serial[USBD_STR_SERIAL_LEN];
 
 		if (index >= sizeof(usbd_desc_str) / sizeof(usbd_desc_str[0]))
 			return NULL;
@@ -108,3 +113,13 @@ const uint16_t *tud_descriptor_string_cb(uint8_t index, uint16_t langid)
 
 	return desc_str;
 }
+
+void usbd_serial_init(void)
+{
+	uint8_t id[8];
+
+	flash_get_unique_id(id);
+
+	snprintf(usbd_serial, USBD_STR_SERIAL_LEN, "%02X%02X%02X%02X%02X%02X%02X%02X",
+		 id[0], id[1], id[2], id[3], id[4], id[5], id[6], id[7]);
+}